KAICO applies its silkworm-based technology platform beyond protein expression, into the development of natural raw materials for supplements, animal nutrition, and cosmetics. Two research programs are currently underway: the cultivation of Cordyceps militaris using silkworms as a host, and the development of silkworm-derived nutritional ingredients for livestock feed.
Cordyceps militaris discovered at Kyushu University
Kyushu University owns an experimental forest in Shiiba Village, Miyazaki Prefecture, spanning 2,916 hectares. Since 1939, this area has been exclusively used for environmental research and studies, and access by the general public is restricted, allowing many plants and animals to thrive and be protected.
In this experimental forest, Professor Kusakabe of Kyushu University discovered Cordyceps militaris, a type of caterpillar fungus. He also succeeded in artificially cultivating this rare mushroom, Cordyceps militaris, using silkworms as the host through inoculation. Cordyceps militaris is a unique mushroom that grows from the pupae of butterflies and moths and is one of the well-known high-grade Chinese herbal medicines.
Highly prized Chinese medicine “Cordyceps militaris”
Cordyceps militaris, a relative of the highly prized traditional Chinese medicinal fungus Cordyceps sinensis, is known to contain beneficial compounds such as cordycepin, superoxide dismutase (SOD), β-glucan, ergosterol, and mannitol. In particular, ‘cordycepin’ possesses functions such as immune activation, anti-obesity, and anti-tumor effects. Between 2011 and 2021, over 1,200 research papers on Cordyceps militaris were published, with more than 500 of them focusing on cordycepin.
Original cultivating method using “living silkworms”
At KAICO, we have developed a method to cultivate Cordyceps militaris in conditions close to nature, in collaboration with Professor Kusakabe. After much trial and error, we have developed an original cultivation method using “living silkworms”, enabling us to stably produce high-quality and rare Cordyceps militaris.
Here is a paper regarding Cordyceps militaris that KAICO has manufactured.
Pure Silkworm Product for Animal Nutrition
Silkworms themselves are a source of high-quality protein and nutrients. KAICO has developed a pure silkworm powder as a natural ingredient for animal feed, produced from silkworms sourced through our network of partner sericulture farmers in Japan.
As a nutritional supplement, this silkworm powder is being evaluated for its contribution to better performance and improved average daily gain (ADG) in livestock. Feeding trials are ongoing with partners across Asia, building on KAICO’s experience in silkworm-based ingredient development.
